This Interactive Learning Module (ILM) reviews critical issues related to atypical antipsychotic agents. Topics include glucose and lipid metabolism, cardiovascular risks, and monitoring guidelines.

This activity is part of a free series. All the activities help you effectively assess and treat bipolar disorder, depression, schizophrenia, and related conditions such as fatigue and cognitive dysfunction.

View the other activities in the series: Massachusetts General Hospital Colloquium: Common Challenges in the Treatment of Mood Disorders and Schizophrenia

Learning Objectives

At the end of this program, participants will be able to:

  • Discuss the potential for weight gain, glucose impairment, and lipid abnormalities with antipsychotic agents.
  • Identify potential mechanisms of medication-associated glucose and lipid metabolism impairment and review several medications' effects on glucose and lipid metabolism.
  • Outline strategies to monitor and manage metabolic effects of antipsychotic agents.

Target Audience

This program is intended for:

  • Psychiatrists
  • Psychologists
  • Primary Care
  • Internal and Family Care Physicians
  • Nurses
  • Other Allied Healthcare Professionals


  • Director, Schizophrenia Clinical and Research Program
    Director, Chester M. Pierce, M.D. Division of Global Psychiatry
    Massachusetts General Hospital
    Associate Professor of Psychiatry
    Harvard Medical School
    Associate Professor of Epidemiology
    Harvard School of Public Health

Educational Support

This program has received support in the form of educational grants from the following companies:

  • Janssen Global Services, LLC
  • Sunovion Pharmaceuticals, Inc.
  • Takeda Pharmaceuticals International, Inc.

CME Information

Release Date: February 16, 2015
Expiration Date: February 16, 2018
Review Date: February 8, 2017 by Robert Althoff, MD

To receive credit for this activity, you must view the presentation and complete the pre test, post test, and evaluation.






AMA PRACategory
1 Credit

This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of McLean Hospital and Massachusetts General Hospital. McLean Hospital is accredited by ACCME to provide continuing medical education for physicians.

McLean Hospital designates this enduring material for a maximum of 0.50AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


Psychologists CE Credit

The Massachusetts General Hospital Department of Psychiatry is approved by the American Psychological Association to sponsor continuing education for psychologists. The Massachusetts General Hospital Department of Psychiatry maintains responsibility for this program and its content.

This offering meets the criteria for 0.50 continuing education credit for psychologists.



Other Professions

Other Providers can claim a Participation Certificate upon successful completion of this course.

Participation Certificates will specify the title, location, type of activity, date of activity, and number ofAMA PRA Category 1 CreditTMassociated with the activity. Providers should check with their regulatory agencies to determine ways in whichAMA PRA Category 1 CreditsTMmay or may not fulfill continuing education requirements. Providers should also consider saving copies of brochures, agenda, and other supporting documents.

Faculty Disclosure Statement

It is the policy of McLean Hospital that faculty and providers disclose real or apparent conflicts of interest relating to the topics of this educational activity. McLean Hospital has established policies in place that identify and resolve all conflicts of interest prior to this educational activity.

Resolution of Conflicts of Interest (COI)

McLean Hospital has implemented a process to resolve COI for each CME activity. In order to help ensure content objectivity, independence, fair balance and ensure that the content is aligned with the interest of the public, McLean Hospital has resolved the conflict by External Content Review.

Planner Disclosures

The following planners and/or their spouse/partner have reported no relevant financial relationship with a commercial interest.

Tristan L. Gorrindo, MD, reviewer
Jane Pimental, MPH

The following planners and/or their spouse/partner have reported a relevant financial relationship with a commercial interest.

Michael Hirsch, MD,reviewer
Honoraria: UpToDate (for writing)

Susan E. Sprich, PhD
Royalties: Oxford University Press (for co-authoring treatment manual and client workbook), Springer (for editing book)

Speaker Disclosures

The following speakers and/or their spouse/partner have reported a relevant financial relationship with a commercial interest.

David Henderson, MD
Speaker: Otsuka Pharmaceuticals
Consultant: Envivo (Forum), Janssen, Reckitt

Hardware/Software Specifications

This internet-based CME activity is best experienced using Internet Explorer 8+, Mozilla Firefox 3+, Safari 4+. This Web site requires that JavaScript and session cookies be enabled. Certain activities may require additional software to view multimedia, presentation, or printable versions of the content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Adobe Acrobat, Microsoft PowerPoint, and Windows Media Player.

Optimal System Configuration

Flash Player: Adobe Flash Player 10.1+
Browser: Firefox 3+, Internet Explorer 8.0+, Safari 4.0+, or Google Chrome 7.0+
Operating System: Windows XP+ or Mac OS X 10.4+
Internet Connection: 1 Mbps or higher

Minimum Requirements

Windows PC:500-MHz Pentium II; Windows XP or higher; 128 MB RAM; Video Card at least 64MB of video memory; Sound Card at least 16-bit; Macromedia Flash Player 10 or higher, audio playback with speakers for programs with video content; Firefox 1.1+, Internet Explorer 7.0+, Safari 1.0+, Google Chrome, or Opera
Macintosh:Mac OS X 10.3 or higher with latest updates installed; 1.83MHz Intel Core Duo or faster; RAM: 128MB or more; Video Card: at least 64MB of video memory; Sound Card: at least 16-bit

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