This Interactive Learning Module (ILM) provides mental health clinicians with an overview of assessment tools that are available for measuring apathy and fatigue in clinical settings. This includes scoring, interpretation, and application to diagnostic use.

This activity is part of a free series. All the activities help you effectively assess and treat bipolar disorder, depression, schizophrenia, and related conditions such as fatigue and cognitive dysfunction.

View the other activities in the series:Massachusetts General Hospital Colloquium: Common Challenges in the Treatment of Mood Disorders and Schizophrenia

Learning Objectives

At the end of this program, participants will be able to:

  • Review different instruments available for measuring apathy and fatigue in the clinical setting.
  • Score these instruments and interpret the scores.
  • Apply these instruments to diagnostic use in the clinical setting.

Target Audience

This program is intended for:

  • Psychiatrists
  • Psychologists
  • Primary Care
  • Internal and Family Care Physicians
  • Nurses
  • Other Allied Healthcare Professionals


  • Director, Depression Clinical and Research Program
    Massachusetts General Hospital

    Associate Professor of Psychiatry
    Harvard Medical School

Educational Support

This program has received support in the form of educational grants from the following companies:

  • Janssen Global Services, LLC
  • Sunovion Pharmaceuticals, Inc.
  • Takeda Pharmaceuticals International, Inc.

CME Information

Release Date: February 16, 2015
Expiration Date: February 16, 2018
Review Date: February 8, 2017 by Robert Althoff, MD

To receive credit for this activity, you must view the presentation and complete the pre test, post test, and evaluation.






AMA PRACategory
1 Credit

This activity has been planned
and implemented in accordance
with the accreditation
requirements and policies of the
Accreditation Council for
Continuing Medical Education
(ACCME) through the joint
providership of McLean Hospital
and Massachusetts General
Hospital. McLean Hospital is
accredited by the ACCME to
provide continuing medical
education for physicians.

McLean Hospital designates this enduring material for a maximum of 0.25AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


Psychologists CE Credit

The Massachusetts General Hospital Department of Psychiatry is approved by the American Psychological Association to sponsor continuing education for psychologists. The Massachusetts General Hospital Department of Psychiatry maintains responsibility for this program and its content.

This offering meets the criteria for 0.25 continuing education credit for psychologists.



Other Professions

Other Providers can claim a Participation Certificate upon successful completion of this course.

Participation Certificates will specify the title, location, type of activity, date of activity, and number ofAMA PRA Category 1 CreditsTMassociated with the activity. Providers should check with their regulatory agencies to determine ways in whichAMA PRA Category 1 CreditsTMmay or may not fulfill continuing education requirements. Providers should also consider saving copies of brochures, agenda, and other supporting documents.


Tristan L. Gorrindo, MD, reviewer
Jane Pimental, MPH
Michael Hirsch, MD,reviewer
Susan Sprich, PhD

Disclosure Information

In accord with the disclosure policy of McLean Hospital as well as guidelines set forth by the Accreditation Council on Continuing Medical Education, all people in control of educational content, including speakers, course directors, planners, and reviewers, have been asked to disclose all relevant financial relationships with commercial interests of both themselves and their spouses/partners over the past 12 months, as defined below:

Commercial Interest

The ACCME defines a "commercial interest" as any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients. The ACCME does not consider providers of clinical service directly to patients to be commercial interests. For more information,

Financial relationships

Financial relationships are those relationships in which the individual benefits by receiving a salary, royalty, intellectual property rights, consulting fee, honoraria, ownership interest (e.g., stocks, stock options or other ownership interest, excluding diversified mutual funds), or other financial benefit. Financial benefits are usually associated with roles such as employment, management position, independent contractor (including contracted research), consulting, speaking and teaching, membership on advisory committees or review panels, board membership, and other activities from which remuneration is received, or expected. ACCME considers relationships of the person involved in the CME activity to include financial relationships of a spouse or partner.

Relevant financial relationships

ACCME focuses on financial relationships with commercial interests in the 12-month period preceding the time that the individual is being asked to assume a role controlling content of the CME activity. ACCME has not set a minimal dollar amount for relationships to be significant. Inherent in any amount is the incentive to maintain or increase the value of the relationship. The ACCME defines "'relevant' financial relationships" as financial relationships in any amount occurring within the past 12 months that create a conflict of interest.

Conflict of Interest

Circumstances create a conflict of interest when an individual has an opportunity to affect CME content about products or services of a commercial interest with which he/she has a financial relationship.

The following planners, speakers, and content reviewers, on behalf of themselves and their spouse or partner, have reported financial relationships with an entity producing, marketing, re-selling, or distributing health care goods or services (relevant to the content of this activity) consumed by, or used on, patients:


Susan Sprich, PhD
Royalties:Oxford University Press (for co-authoring treatment manual and client workbook), Springer (for co-editing book)

Michael Hirsch, MD,reviewer
Honoraria: UpToDate (for writing)


David Mischoulon, MD, PhD
Research support:Bowman Family Foundation, Fisher Wallace, Nordic Naturals, Methylation Sciences, Inc. (MSI), and PharmoRx Therapeutics (Principal Investigator)
Honoraria:Pamlab and Massachusetts General Hospital Psychiatry Academy (for speaking)
Royalties: Lippincott Williams & Wilkins (for editing and writing published book "Natural Medications for Psychiatric Disorders: Considering the Alternatives")

All other individuals including course directors, planners, reviewers, faculty, staff, etc., who are in a position to control the content of this educational activity have, on behalf of themselves and their spouse or partner, reported no financial relationships related to the content of this activity.

Educational Support

This program has received support in the form of educational grants from

  • Janssen Global Services, LLC
  • Sunovion Pharmaceuticals, Inc.
  • Takeda Pharmaceuticals International, Inc.

Hardware/Software Specifications

This internet-based CME activity is best experienced using Internet Explorer 8+, Mozilla Firefox 3+, Safari 4+. This Web site requires that JavaScript and session cookies be enabled. Certain activities may require additional software to view multimedia, presentation, or printable versions of the content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Adobe Acrobat, Microsoft PowerPoint, and Windows Media Player.

Optimal System Configuration

Flash Player: Adobe Flash Player 10.1+
Browser: Firefox 3+, Internet Explorer 8.0+, Safari 4.0+, or Google Chrome 7.0+
Operating System: Windows XP+ or Mac OS X 10.4+
Internet Connection: 1 Mbps or higher

Minimum Requirements

Windows PC:500-MHz Pentium II; Windows XP or higher; 128 MB RAM; Video Card at least 64MB of video memory; Sound Card at least 16-bit; Macromedia Flash Player 10 or higher, audio playback with speakers for programs with video content; Firefox 1.1+, Internet Explorer 7.0+, Safari 1.0+, Google Chrome, or Opera
Macintosh:Mac OS X 10.3 or higher with latest updates installed; 1.83MHz Intel Core Duo or faster; RAM: 128MB or more; Video Card: at least 64MB of video memory; Sound Card: at least 16-bit

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