Holt, Daphne, MD

Co-director, Schizophrenia Clinical and Research Program
Massachusetts General Hospital
Associate Professor, Harvard Medical School


Dr. Daphne Holt is currently an Associate Professor at Harvard Medical School and Co-director of the Schizophrenia Clinical and Research Program, as well as Director of the Emotion and Social Neuroscience Laboratory and the Resilience Enhancement and Prevention Program.

Dr. Holt attended medical school at the University of Chicago Pritzker School of Medicine, where she also received a PhD in neurobiology. She received her training in psychiatry in the Massachusetts General/McLean Hospital adult psychiatry residency program, becoming a faculty member of the Massachusetts General Hospital Psychiatry Department in 2004. 

Dr. Holt’s research focuses on understanding the neural basis of emotional function and social behavior, and abnormalities in these domains in neuropsychiatric disorders such as schizophrenia. She is also beginning to identify changes in these systems in young people who are at risk for neuropsychiatric disorders, in an effort to develop methods to detect these changes before the onset of these illnesses. She also oversees a clinical program that focuses on enhancing emotional resilience in order to reduce risk for neuropsychiatric illness.

She has published peer-reviewed articles in journals such as Molecular Psychiatry, The Journal of Neuroscience, Neuroscience, The Journal of Cognitive Neuroscience, Biological Psychiatry, Schizophrenia Bulletin and the Archives of General Psychiatry among others. Her research has been supported by grants from the National Institute of Mental Health as well as several foundations including the National Alliance for Research on Schizophrenia And Depression (now known as the Brain & Behavior Research Foundation), the Sidney R. Baer, Jr Foundation, the Kennedy Smith Foundation, the Jerome Lyle Rappaport Charitable Foundation, and the Institute for Mental Illness and Neuroscience Discovery.