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Holt, Daphne, MD, PHD

Schizophrenia Clinical and Research Program
Massachusetts General Hospital

Emotion and Social Neuroscience Laboratory
Massachusetts General Hospital

Resilience Enhancement and
Prevention Program
Massachusetts General Hospital

Associate Professor of Psychiatry
Harvard Medical School


Dr. Daphne J. Holt is an Associate Professor of Psychiatry at Harvard Medical School. She serves as Director of the Emotion and Social Neuroscience Laboratory at Massachusetts General Hospital (MGH), Director of the Resilience  Program at MGH, and Co-Director of the MGH Schizophrenia Clinical and Research Program.

Dr. Holt attended medical school at the University of Chicago Pritzker School of Medicine, where she also received a PhD in neurobiology. She received her training in psychiatry in the Massachusetts General/McLean Hospital adult psychiatry residency program, becoming a faculty member of the Massachusetts General Hospital Psychiatry Department in 2004. 

Dr. Holt’s research focuses on understanding the neural basis of emotional function and social behavior, and abnormalities in these domains in neuropsychiatric disorders such as schizophrenia. She is also beginning to identify changes in these systems in young people who are at risk for neuropsychiatric disorders, in an effort to develop methods to detect these changes before the onset of these illnesses. She also oversees a clinical program that focuses on reducing risk for neuropsychiatric illness.

She has published numerous peer-reviewed articles in journals such as Molecular Psychiatry, Journal of Neuroscience, Neuroscience, The Journal of Cognitive Neuroscience, Biological Psychiatry, Schizophrenia Bulletin, and the Archives of General Psychiatry, among others. Her research has been supported by grants from the National Institute of Mental Health as well as several foundations including the National Alliance for Research on Schizophrenia And Depression, and the Sidney R. Baer, Jr. Foundation.