Worthington, John, MD

Staff Psychiatrist, Center for Anxiety and Traumatic Stress Disorders, MGH
Assistant Professor of Psychiatry, Harvard Medical School


Dr. John Worthington is a Staff Psychiatrist at the Center for Anxiety and Traumatic Stress Disorders at the Massachusetts General Hospital, and Assistant Professor of Psychiatry at Harvard Medical School. He received his medical degree from Georgetown University School of Medicine in Washington, D.C., completed his residency at the University of North Carolina Hospitals in Chapel Hill, N.C. and did a research fellowship in Clinical Psychopharmacology at the Massachusetts General Hospital.

Currently, Dr. Worthington is an investigator on several National Institutes of Mental Health studies involving the course of treatment-refractory panic disorder, treatment-resistant depression, and the predication of outcome during antidepressant discontinuation. He is also an investigator in numerous phase II and phase III clinical trials sponsored by several pharmaceutical companies. He has published over 110 articles, reviews and posters and he lectures in national and international forums.

Dr. Worthington's areas of clinical interest include the effects of alcohol and substance use on mood and anxiety disorders, acute and long-term treatment of patients with panic disorder and depression, development of novel pharmacologic agents for mood and anxiety disorders, and uses of combined cognitive-behavioral and pharmacologic therapies for treatment-refractory patients.


Neither Dr. Worthington nor any member of his family has relevant financial relationships with any commercial interests.