Course Director Franklin King, MD, presents this annual conference as a clinically focused examination of the rapidly evolving field of psychedelic medicine. The program offers up-to-date overviews and critical discussions of current research in psychedelics and psychedelic-assisted therapies, with a clear emphasis on clinical evidence and real-world practice. Sessions will explore proposed mechanisms of action—including pharmacology, neuroscience, and psychodynamic frameworks—while grounding these concepts in the treatment of specific clinical conditions such as depression, PTSD, and substance use disorders. In addition, expert panels and presentations will address ethical considerations, historical context, cultural perspectives, and the role of plant-based medicines, providing clinicians with a balanced, academically rigorous view of this emerging therapeutic landscape.